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Primary Characteristics PharmacoKinetics Indications Contra Indication
InteractionInterference in Pathology Side Effects Available Brands
Dosage High Risk Groups Warning / Precautions Storage Conditions
Simvastatin
Introduction

Simvastatin is antihyperlipidic agent. Simvastatin is structural analog of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme). Like other agents, it inhibits the enzyme hydroxymethylglutaryl-CoA (HMG-CoA) reductase. It has an extremely high affinity for this enzyme and was considered the most potent agent of the HMG-CoA class until atorvastatin was approved. Simvastatin is inactive lactone prodrug and hydrolyzed in the gastrointestinal tract to the active ß hydroxy derivative. It was approved by the FDA in December 1991. It decreases total cholesterol, LDL cholesterol, triglycerides, and apolipoprotein B, while increasing HDL.

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