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Simvastatin

Overview

Simvastatin is antihyperlipidic agent. Simvastatin is structural analog of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme). Like other agents, it inhibits the enzyme hydroxymethylglutaryl-CoA (HMG-CoA) reductase. It has an extremely high affinity for this enzyme and was considered the most potent agent of the HMG-CoA class until atorvastatin was approved. Simvastatin is inactive lactone prodrug and hydrolyzed in the gastrointestinal tract to the active ß hydroxy derivative. It was approved by the FDA in December 1991. It decreases total cholesterol, LDL cholesterol, triglycerides, and apolipoprotein B, while increasing HDL.

Category:

Primary Characterstics

Molecular Structure of Simvastatin
Simvastatin also known as Synvinolin. . It is of Synthetic origin and belongs to Lactone. It belongs to HMGCoA reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.The Molecular Weight of Simvastatin is 418.60.

Pharmacokinetics

Oral absorption of Simvastatin is found to be 42.5% ±42.5. Volume of distribution is found to be 98% and plasma protien binding is ~95%. Presystemic metabolism is noted to be 83% ±7 and metabolism is reported Hepatic. Renal Excretion accounts for 13% and plasma half life is 1.9 hr.

Indications

Interactions

Simvastatin is known to interact with other drugs like Amiodarone (HCl), Amprenavir, Atazanavir, Bosentan, Ciprofibrate, Colestipol (HCl), Danazol, Digoxin, Itraconazole, Ketoconazole, Linagliptin, Mibefradil (Di HCl), Telithromycin, Ticagrelor, Toclizumab, Warfarin (Na).

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

  • Increased Alkaline Phosphatase Levels
  • Elevaions in creatinine phosphokinase levels

Side Effects

The severe or irreversible adverse effects of Simvastatin, which give rise to further complications include Acute renal failure.

The symptomatic adverse reactions produced by Simvastatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Headache, Fatigue, Nausea, Diarrhea, Constipation, Abdominal pain, Elevation of liver enzymes, Myopathy, Rhabdomyolysis, Muscle tenderness, Increased intracranial pressure, Hepatitis, Pancreatitis.

Available Brands

Dosage

Simvastatin's dosage details are as follows:
Dose Single Dose Frequency Route Instructions
Adult Dosage

5.000 to 80.000 mg

42 (42.5)

24 hourly

PO

In evening, maintenance dose ranges 5-40 mg.

Paedriatic Dosage ( 20 Kg. )

Not recommended in this age group

Neonatal Dosage ( 3 Kg. )

Not recommended in this age group

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Use simvastatin with caution in patients with liver disease, severe infection, kidney disease, heart disease, hypothyroidism, history of alcoholism or any allergy, especially drug allergies. Limit alcohol intake as it may aggravate side effects. Simvastatin should not be used during pregnancy or lactation.

Storage Conditions

Tab

Store Below 40°C. Protect from Sunlight and Moisture.

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