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Manufacturer(s) of Levofloxacin in Pakistan.

AdamjeeAdvanced
AhadAksonAlfalah Pharma
AliedAlinaAlkemy
AllianceAmbrosiaAmros
AnkazArdinAries
AsianAskariAtco
AventisBarrettBasel
BatalaBaxterBayer
BensonBio PharmaBiogen
BiogenicsBiolabsBiorex
BloomBoschBreeze
BrookesBryonCandid
CarawayCaylexCCL
CherwelChiesiCirin
CityCrestCSH
DanasDavisDelta
Don valleyDr.RazaDyson R L
E PharmEfrozeEG Pharma
ElkoEnglishEnvoy
EplaEpochEros
EthicalEverestEvergreen
FassgenFedroFerozson
FerrozaFlorenceFlow
FOCUS & RULZFozanFriends
FrontierFynkGaba
GeneraGenixGenome
GeofmanGetzGillman
GlitzGlobalGoodman
Goodman LGray'sHansel
HealHeliconHelix
High-QHighnoonHilton
HisunHonigHumayun
IdealImcoIndus
InnvotekISISJawa
JaysonJinnahKCI
KobecLahore PharmaLawari
LEADSLeamaLegacy
LibraLinearLotus
LowittMac & RansMacquins
MacterMapleMarion
MassMaxMBL
MederaMediateMedicaids
MediceenaMedicinecoMedicon
MedicraftMedifineMedimarkers
MedipakMEDISAVEMedisure
MedisynthMedizan LabMeezab Int.
Mega PharmaMendozaMerck
MiracleMunawarMyrtle
NabiqasimNavegalNenza
NeoNeutroNexus
NimrallNoa HemisNovamed
NovartisNovinsObsons
Olive LabsOpalOrta
OttomanPacificPakheim
PanaceaParamountPDH
PearlPfizerPharma Health
PharmacarePharmatecPharmevo
PharmixPlatinumPliva
PolyfinePopularPPP
PulseQintarRaazee
RakaposhiRascoRay
RehmanRehmatReko
RelianceRockRogen
Roryan PharmaRotexS.J.& G
SaaafSaffronSami
SaturnSaydonSayyad
ScotmannSearleSelmore
SemosShaheen PharmaShaigan
ShawanShazalShrooq
SiamSilverSiza
SPLStandardStandpharm
SunshineSwanSwiss Pharma
SyntexTabrosTagma
TechnovisionTRISONUmersons
UnimarkUnit TiechUsawa
ValorVertexWarafana
WebroseWellWellborne
WelmarkWelwrdWerrick
WilshireWilsonsWinilton
WiseWnsFeildWoodward
Z-JansZafaZaka
ZanctokZephyrZesion
ZintaZumars

Levofloxacin

Overview

Levofloxacin is a fluoroquinolone antibiotic available for oral or intravenous administration. Levofloxacin is the optically active L-isomer of ofloxacin. It has a slightly longer half-life than ofloxacin and can be administered once-daily. Levofloxacin is more active than ofloxacin against staphylococci and streptococci. Levofloxacin is FDA approved for the treatment of sinusitis, chronic bronchitis, community-acquired pneumonia, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis. It tablets and injection were FDA approved for the treatment these infections on 12/20/96. It inhibits bacterial DNA gyrase, a type II topoisomerase. Topoisomerases alter DNA by introducing superhelical twists into double-stranded DNA and by facilitating unwinding of DNA strands

Category:

  • 6 Anti-infective drugs
  • 6.2 Antibiotics, systemic
  • 6.2.2 Other anti-bacterial drugs
  • 6.2.2.2 Quinolones

Primary Characterstics

Molecular Structure of Levofloxacin
. It is of Semi Synthetic origin and belongs to Piperazine. It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Levofloxacin is 361.40.

Pharmacokinetics

Oral absorption of Levofloxacin is found to be 99% ±10. Volume of distribution is found to be 1.36l/kg and plasma protien binding is 30-40%. Renal Excretion accounts for > 85% and plasma half life is 6 - 8 hr.

Indications

Contraindications

Levofloxacin is contraindicated in conditions like Hypersensitivity.

Drug Interactions

Levofloxacin is known to interact with other drugs, the details of drug interactions is as follows:

DrugDetailsSeverityOnsetManagement
Aluminium Hydroxide and OxideAluminium and magnesium hydroxide containing antacids, and products containing calcium, ion and zinc salts reduce the absorption of levofloxacin.
Cyclosporin AConcomitant use of levofloxacin and cyclosporin increases nephrotoxicity.
FenbufenUse of fenbufen with quinolones may increase the incidence of quinolone CNS adverse effects.
ProbenecidThe urinary excretion of levofloxacin is reduced by probenecid; plasma concentration are not necessarily increased.
TheophyllineLevofloxacin decrease the clearance of theophylline and caffeine.
VORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation
Warfarin (Na)Levofloxacin enhances the effect of oral anticoaggulants.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

  • Elevation in BUN
  • False-positive urine screening results
  • False-positive urine screening results
  • elevated creatinine

Side Effects

The severe or irreversible adverse effects of Levofloxacin, which give rise to further complications include Stevens johnson syndrome, Epidermal necrolysis, Stevens johnson syndrome, Epidermal necrolysis, Tendon rupture, QT prolongation.

Levofloxacin produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Levofloxacin therapy.

The signs and symptoms that are produced after the acute overdosage of Levofloxacin include QT prolongation.

The symptomatic adverse reactions produced by Levofloxacin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Diarrhea, Anxiety, Restlessness, Constipation, Abdominal pain, Confusion, Pruritus, Vaginitis, Hallucination, Dyspepsia, Depression, Nightmares, Chest pain, Hypoglycemia, Confusion, dizziness, dyspepsia.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 40 mg, 5 mg/ml, 2.5 mg/ml, 7.5 mg/ml,
Inj-IV: 500 mg,
Inf: 5 mg/ml, 2.5 mg/ml, 7.5 mg/ml,
Eye Drops: 0.5 %w/v,
Syrup: 250 mg/5ml, 500 mg/5ml,
Susp: 125 mg/5ml, 250 mg/5ml, 500 mg/5ml,
Tabs: 200 mg, 250 mg, 400 mg, 500 mg, 750 mg,
Caps: 250 mg, 500 mg, 750 mg,

Multi ingredient

Inf: 7.5 mg,

Dosage

Levofloxacin's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

500 mg500 (500)12 hourlyIV
250 to 500 mg380 (375)12 hourlyPO

Paedriatic Dosage ( 20 Kg. )

Not recommende for this age group
10 mg/kg10 (10)As recommended.

Neonatal Dosage ( 3 Kg. )

No data regarding the neonatal dosage details of Levofloxacin is available.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Levofloxacin should be used with caution in patients with epilepsy, kidney disease, tendon problems, nervous system disorders, liver disease and of any allergy, including drug allergy. It should be used with caution while driving or performing tasks requiring alertness because it causes dizziness, lightheaded or drowsiness. Limit alcohol intake. Because this may cause sensitivity to the sun, so avoid prolonged sun exposure, wear protective clothing and use a sunscreen when outdoors. Caution is advised when this drug is used in children under 18 years of age. It should be used only when clearly needed during pregnancy. It is not recommended during lactation.

Storage Conditions

Inj (Reconstituted soln)

Store at room temperature or refrigerator. Do not Freeze. Protect from Sunlight and Heat. Use within 2 weeks if refrigerated and within 2 weeks if kept at room temperature.

Tab

Store Below 30°C. Protect from Sunlight and Moisture.

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