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Primary Characteristics PharmacoKinetics Indications Contra Indication
InteractionInterference in Pathology Side Effects Available Brands
Dosage High Risk Groups Warning / Precautions Storage Conditions
Levofloxacin
Introduction

Levofloxacin is a fluoroquinolone antibiotic available for oral or intravenous administration. Levofloxacin is the optically active L-isomer of ofloxacin. It has a slightly longer half-life than ofloxacin and can be administered once-daily. Levofloxacin is more active than ofloxacin against staphylococci and streptococci. Levofloxacin is FDA approved for the treatment of sinusitis, chronic bronchitis, community-acquired pneumonia, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis. It tablets and injection were FDA approved for the treatment these infections on 12/20/96. It inhibits bacterial DNA gyrase, a type II topoisomerase. Topoisomerases alter DNA by introducing superhelical twists into double-stranded DNA and by facilitating unwinding of DNA strands

Category:

  • 6 Anti-infective drugs
  • 6.2 Antibiotics, systemic
  • 6.2.2 Other anti-bacterial drugs
  • 6.2.2.2 Quinolones

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