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Manufacturer(s) of Levofloxacin in Pakistan.

AdamjeeAdvanced
AhadAksonAlfalah Pharma
AliedAlinaAlkemy
AllianceAmbrosiaAmros
AnkazArdinAries
AsianAskariAtco
AventisBarrettBasel
BatalaBaxterBayer
BensonBio PharmaBiogen
BiolabsBiorexBloom
BoschBreezeBrookes
BryonCandidCaraway
CaylexCCLCirin
CityCrestCSH
DanasDavisDelta
Don valleyDr.RazaDyson R L
E PharmEfrozeElko
EnglishEnvoyEpla
EpochErosEthical
EverestEvergreenFassgen
FedroFerozsonFerroza
FlorenceFlowFOCUS & RULZ
FozanFriendsFrontier
FynkGabaGenera
GenixGenomeGeofman
GetzGillmanGlitz
GlobalGoodmanGoodman L
Gray'sHanselHeal
HeliconHelixHigh-Q
HighnoonHiltonHisun
HonigHumayunIdeal
ImcoIndusInnvotek
ISISJawaJayson
JinnahKCIKobec
Lahore PharmaLawariLEADS
LeamaLegacyLibra
LinearLotusLowitt
Mac & RansMacquinsMacter
MapleMarionMass
MaxMBLMedera
MediateMedicaidsMediceena
MediconMedicraftMedifine
MedimarkersMedipakMEDISAVE
MedisureMedisynthMedizan Lab
Meezab Int.Mega PharmaMendoza
MerckMiracleMyrtle
NabiqasimNavegalNenza
NeoNeutroNexus
NimrallNoa HemisNovamed
NovartisNovinsObsons
Olive LabsOpalOrta
OttomanPacificPakheim
PanaceaParamountPDH
PearlPfizerPharma Health
PharmacarePharmevoPharmix
PlatinumPlivaPolyfine
PopularPPPPulse
RaazeeRakaposhiRasco
RayRehmanRehmat
RekoRelianceRock
RogenRoryan PharmaRotex
S.J.& GSaaafSaffron
SamiSaturnSaydon
SayyadScotmannSearle
SelmoreSemosShaheen Pharma
ShaiganShawanShazal
ShrooqSiamSilver
SizaSPLStandard
StandpharmSunshineSwan
Swiss PharmaSyntexTabros
TagmaTechnovisionTRISON
UmersonsUnimarkUnit Tiech
UsawaValorVertex
WarafanaWebroseWell
WellborneWelmarkWelwrd
WerrickWilshireWilsons
WiniltonWiseWnsFeild
WoodwardZ-JansZafa
ZakaZanctokZephyr
ZesionZintaZumars

Levofloxacin

Overview

Levofloxacin is a fluoroquinolone antibiotic available for oral or intravenous administration. Levofloxacin is the optically active L-isomer of ofloxacin. It has a slightly longer half-life than ofloxacin and can be administered once-daily. Levofloxacin is more active than ofloxacin against staphylococci and streptococci. Levofloxacin is FDA approved for the treatment of sinusitis, chronic bronchitis, community-acquired pneumonia, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis. It tablets and injection were FDA approved for the treatment these infections on 12/20/96. It inhibits bacterial DNA gyrase, a type II topoisomerase. Topoisomerases alter DNA by introducing superhelical twists into double-stranded DNA and by facilitating unwinding of DNA strands

Category:

  • 6 Anti-infective drugs
  • 6.2 Antibiotics, systemic
  • 6.2.2 Other anti-bacterial drugs
  • 6.2.2.2 Quinolones

Primary Characterstics

Molecular Structure of Levofloxacin
. It is of Semi Synthetic origin and belongs to Piperazine. It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Levofloxacin is 361.40.

Pharmacokinetics

Oral absorption of Levofloxacin is found to be 99% ±10. Volume of distribution is found to be 1.36l/kg and plasma protien binding is 35%. Renal Excretion accounts for > 85% and plasma half life is 6 - 8 hr.

Indications

Contraindications

Levofloxacin is contraindicated in conditions like Hypersensitivity.

Drug Interactions

No data regarding the interactions of Levofloxacin was found.

Interference in Pathology

  • Elevation in BUN
  • False-positive urine screening results
  • False-positive urine screening results
  • elevated creatinine

Side Effects

The severe or irreversible adverse effects of Levofloxacin, which give rise to further complications include Stevens johnson syndrome, Epidermal necrolysis, Tendon rupture, QT prolongation.

Levofloxacin produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Levofloxacin therapy.

The signs and symptoms that are produced after the acute overdosage of Levofloxacin include QT prolongation.

The symptomatic adverse reactions produced by Levofloxacin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Diarrhea, Anxiety, Restlessness, Constipation, Abdominal pain, Confusion, Pruritus, Hallucination, Dyspepsia, Depression, Nightmares.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 40 mg, 500 mg, 5 mg/ml, 2.5 mg/ml, 7.5 mg/ml,
Inj-IV: 500 mg,
Inf: 5 mg, 500 mg, 5 mg/ml, 2.5 mg/ml, 7.5 mg/ml, 250 mg/50ml, 500 mg/100ml,
Eye Drops: 0.5 %w/v,
Syrup: 250 mg/5ml, 500 mg/5ml,
Susp: 125 mg, 250 mg, 125 mg/5ml, 250 mg/5ml,
Tabs: 40 mg, 200 mg, 250 mg, 500 mg, 750 mg,
Caps: 250 mg, 500 mg, 750 mg,

Multi ingredient

Inf: 7.5 mg,
Tabs: 250 mg, 500 mg,

Dosage

Levofloxacin's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

500 mg500 (500)12 hourlyIV
250 to 500 mg380 (375)12 hourlyPO

Paedriatic Dosage ( 20 Kg. )

Not recommende for this age group

Neonatal Dosage ( 3 Kg. )

No data regarding the neonatal dosage details of Levofloxacin is available.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Levofloxacin should be used with caution in patients with epilepsy, kidney disease, tendon problems, nervous system disorders, liver disease and of any allergy, including drug allergy. It should be used with caution while driving or performing tasks requiring alertness because it causes dizziness, lightheaded or drowsiness. Limit alcohol intake. Because this may cause sensitivity to the sun, so avoid prolonged sun exposure, wear protective clothing and use a sunscreen when outdoors. Caution is advised when this drug is used in children under 18 years of age. It should be used only when clearly needed during pregnancy. It is not recommended during lactation.

Storage Conditions

Inj (Reconstituted soln)

Store at room temperature or refrigerator. Do not Freeze. Protect from Sunlight and Heat. Use within 2 weeks if refrigerated and within 2 weeks if kept at room temperature.

Tab

Store Below 40°C. Protect from Sunlight and Moisture.

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