Domperidone

Overview

Domperidone is a dopamine blocking agent. Domperidone is antiemetic agent. Domperidone is also used to treat nausea and vomiting induced by cancer chemotherapy.

Category:

Primary Characterstics

Molecular Structure of Domperidone
. It is of Synthetic origin and belongs to Benzimidazolin. It belongs to Antiemetic/Antivertigo Agents pharmacological group.The Molecular Weight of Domperidone is 425.90.
Its pKa is 7.9.

Pharmacokinetics

Oral absorption of Domperidone is found to be 46.5% ±46.5. Volume of distribution is found to be 5.7 l/kg and plasma protien binding is 91-93%. Presystemic metabolism is noted to be 85% ±2 and metabolism is reported extensively by liver & Gut. Renal Excretion accounts for major 31% and 66% in feces and plasma half life is 12-16 hr (oral), 7.5 hr (parentral).

Indications

Contraindications

Domperidone is contraindicated in conditions like Allergy,Hepatic impairment,Serious resistant GI mycoses.

Drug Interactions

Domperidone is known to interact with other drugs, the details of drug interactions is as follows:

DrugDetailsSeverityOnsetManagement
ApomorphineApomorphine antagonize the action of domperidone.
Bromocriptine (Mesylate)Hypoprolactenamic effect of bromocriptine possibly antagonized by Domperidone.
Bromocriptine (Mesylate)Hyperprolactanemia effect of Bromocriptine possibly antagonized by Domperidone.
CabergolineHypoprolactinemic and antiparkinsonian effects of Cabergoline possibly antagonized by Domperidone.
Cinnarizine
Lisuride
OxycodoneOxycodone antagonize the action of domperidone.
Pergolide
PiribedilDomperidone reduce the effect of piribedil.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

  • Not well documented

Side Effects

The severe or irreversible adverse effects of Domperidone, which give rise to further complications include Tardive dyskinesia, Parkinsonism, Extrapyramidal dystonic reactions.

Domperidone produces potentially life-threatening effects which include Seizures, Dysrhythmias. which are responsible for the discontinuation of Domperidone therapy.

The signs and symptoms that are produced after the acute overdosage of Domperidone include Convulsions, Coma, GI disturbances, Extrapyramidal effects.

The symptomatic adverse reactions produced by Domperidone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thirst, Headache, Drowsiness, Diarrhea, Anxiety, Restlessness, Insomnia, Nervousness, Skin rashes, Dry mouth, Itching, Galactorrhea, Breast enlargement, Soreness, Hyperprolactinemia, nervousness, Reduced libido.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 5 mg/ml,
Syrup: 5 mg/5ml,
Susp: 5 mg, 10 mg, 1 mg/ml, 5 mg/5ml, 100 mg/5ml, 120 mg/5ml,
Tabs: 10, 5 mg, 10 mg, 15 mg, 30 mg, 1 mg/ml, 19.1 mg, 12.72 mg,
Vag Tabs: 10 mg,

Multi ingredient

Tabs: 15 mg, 19.1 mg,

Dosage

Domperidone's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

10 to 20 mg15 (15)6 hourlyPO15-30 minutes before meal. It can be used for maximum 12 weeks.
30 to 60 mg45 (45)6 hourlySuppository

Paedriatic Dosage ( 20 Kg. )

0.2 to 0.4 mg/kg0.3 (0.3)8 hourlyOral15-30 minutes before meal. It can be used for maximum 12 weeks.
30 to 120 mg75 (75)8 hourlySuppository

Neonatal Dosage ( 3 Kg. )

0.2 to 0.4 mg/kg0.3 (0.3)8 hourlyOral-

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Domperidone should be used with great caution if given intravaneously, because of the risk of arrhythmias, especially to patients predisposed to cardiac arrhythmias or hypokalaemia.

Storage Conditions

Tab

Store Below 25°C.

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