Domperidone is a dopamine blocking agent. Domperidone is antiemetic agent. Domperidone is also used to treat nausea and vomiting induced by cancer chemotherapy.
. It is of Synthetic origin and belongs to Benzimidazolin. It belongs to Antiemetic/Antivertigo Agents pharmacological group.The Molecular Weight of Domperidone is 425.90. Its pKa is 7.9.
Oral absorption of Domperidone is found to be 69.75% ±23.25. Volume of distribution is found to be 5.7 l/kg and plasma protien binding is 91-93%. Presystemic metabolism is noted to be 43.5% ±41.5 and metabolism is reported extensively by liver & Gut. Renal Excretion accounts for major 31% and 66% in feces and plasma half life is 12-16 hr (oral), 7.5 hr (parentral).
Domperidone is primarily indicated in conditions like
Acute nausea and vomiting, Delayed gastric emptying, Dyspepsia, Functional dyspepsia, Gastric distension pain due to pressure on the stomach, Gastro-oesophageal reflux disease, Nausea and vomiting, Nausea and vomiting (chemotherapy induced), Nausea and vomiting (L-dopa induced), Non-ulcer dyspepsia, Reflux oesophagitis, and can also be given in adjunctive therapy as an alternative drug of choice in Cytotoxic chemotherapy, Heart burn, Lactation.
Domperidone is known to interact with other drugs, the details of drug interactions is as follows:
Drug Details Severity Onset Management Apomorphine Apomorphine antagonize the action of domperidone. Bromocriptine (Mesylate) Hypoprolactenamic effect of bromocriptine possibly antagonized by Domperidone. Bromocriptine (Mesylate) Hyperprolactanemia effect of Bromocriptine possibly antagonized by Domperidone. Cabergoline Hypoprolactinemic and antiparkinsonian effects of Cabergoline possibly antagonized by Domperidone. Cinnarizine Lisuride Oxycodone Oxycodone antagonize the action of domperidone. Pergolide Piribedil Domperidone reduce the effect of piribedil.
These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interference in Pathology
The severe or irreversible adverse effects of Domperidone, which give rise to further complications include Tardive dyskinesia, Parkinsonism, Extrapyramidal dystonic reactions.
Domperidone produces potentially life-threatening effects which include Seizures, Dysrhythmias. which are responsible for the discontinuation of Domperidone therapy.
The signs and symptoms that are produced after the acute overdosage of Domperidone include Convulsions, Coma, GI disturbances, Extrapyramidal effects.
The symptomatic adverse reactions produced by Domperidone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thirst, Headache, Drowsiness, Diarrhea, Anxiety, Restlessness, Insomnia, Nervousness, Skin rashes, Dry mouth, Itching, Galactorrhea, Breast enlargement, Soreness, Hyperprolactinemia, nervousness, Reduced libido.
Click on the appropriate strength of the dosage form to view its available brands.
Single Ingredient Inj: 5 mg/ml, Syrup: 5 mg/5ml, Susp: 1 mg/ml, 5 mg/5ml, 10 mg/5ml, 100 mg/5ml, 120 mg/5ml, Tabs: 1 mg, 5 mg, 10 mg, 15 mg, 30 mg, 19.1 mg, 12.72 mg, Vag Tabs: 10 mg, Multi ingredient
Tabs: 15 mg, 19.1 mg,
Domperidone's dosage details are as follows:
10 to 20 mg 15 (15) 6 hourly PO 15-30 minutes before meal. It can be used for maximum 12 weeks.
30 to 60 mg 45 (45) 6 hourly Suppository
Paedriatic Dosage ( 20 Kg. )
250 to 0.4 ug/kg 130 (125.2) 8 hourly Oral 15-30 minutes before meal. It can be used for maximum 12 weeks. To a total daily dose of 80mg.
30 to 120 mg 75 (75) 8 hourly Suppository
Neonatal Dosage ( 3 Kg. )
0.2 to 0.4 mg/kg 0.3 (0.3) 8 hourly Oral -
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Warning / Precautions
Domperidone should be used with great caution if given intravaneously, because of the risk of arrhythmias, especially to patients predisposed to cardiac arrhythmias or hypokalaemia.
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