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Glucose

Overview

Glucose is aldohexose also known as dextrose, occuring as the D-form and found as a free monosaccharide in fruits and other plants and in the normal blood of all animals. Glucose is the chief source of energy for living organisms, its utilization is being controlled by insulin.

Category:

Primary Characterstics

Molecular Structure of Glucose
Glucose also known as Dextrose, Dextrose. . It is of Synthetic origin and belongs to Carbohydrate. It belongs to Parenteral Nutrition pharmacological group.The Molecular Weight of Glucose is 180.20.

Pharmacokinetics

Oral absorption of Glucose is found to be 100% . Volume of distribution is found to be 11.4-24.5 litre and plasma protien binding is negligible. Plasma half life is 43 min.

Indications

Glucose is primarily indicated in conditions like Carbohydrate depletion, Dehydration, Energy source, Fluid depletion, Hypoglycaemia, Water replacement, and can also be given in adjunctive therapy as an alternative drug of choice in Cerebral oedema, Varicose veins.

Contraindications

Drug Interactions

Glucose is known to interact with other drugs, the details of drug interactions is as follows:

DrugDetailsSeverityOnsetManagement
Cyanocobalamin
Ispaghula
Kanamycin (Acid Sulphate)
Warfarin (Na)

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

No data regarding the pathological interferences produced by Glucose is available.

Side Effects

The severe or irreversible adverse effects of Glucose, which give rise to further complications include Anaphylactoid reactions, Seizures, Water intoxication, Diabetes mellitus.

Glucose produces potentially life-threatening effects which include Coma, Heart failure, Edema, Sodium retention. which are responsible for the discontinuation of Glucose therapy.

The symptomatic adverse reactions produced by Glucose are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thrombophlebitis, Hypokalemia, Hypomagnesemia, Paresthesias, Hypophosphatemia, Vein irritation, Pain at injection site.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 3.3 g, 5 %w/v, 10 %w/v, 25 %w/v, 5000 IU,
Inj-IV: 5 %w/v, 25 %w/v,
Inf: 5 g, 25 g, 5 %w/v, 10 %w/v, 25 %w/v,
Soln: 5 %w/v,

Multi ingredient

Inj: 5 %w/v, 4.3 %w/v, 8.25 %w/v,
Inf: 5 g/L, 5 %w/v, 1.5 g/L, 10 %w/v, 1.5 %w/v, 3.3 %w/v, 4.25 g/L, 4.3 %w/v, 135 g/1000ml,
Syrup: 10 g/500ml, 3.96 mg/5ml,
Soln: 17 g/L, 5 %w/v, 10 g/500ml, 10 mg/500ml, 15 g/1000ml,
Oral Soln: 20 g, 10 g/500ml,
Liquid: 10 g/500ml, 100 mg/5ml,
Sachet: 20 g, 13.5 g, 13.5 gm, 3.56 g/5.177,
Powder: 20 g/Sachet,

Dosage

Glucose's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

2.5 to 10 %6.2 (6.25)As recommended.IV InfAs required
1000 mg/ kg/hr1000 (1000)As recommended.IV InfAs Required

Paedriatic Dosage ( 20 Kg. )

No data regarding the Paedriatic dosage details of Glucose is available.

Neonatal Dosage ( 3 Kg. )

No data regarding the neonatal dosage details of Glucose is available.

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Perform clinical evaluations and laboratory determination to monitor fluid balance, electrolytes concentration and acid-base balance. There may be the chances of hyperglycemia and glycosuria in such conditions slow the infusion rate monitor blood or urine glucose, if necessary administered insulin. When concentrated glucose infusion is abruptly withdrawn, administered 5% or 10% glucose.

Storage Conditions

Inj

Store in a well closed container, Below 25°C.

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