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Nicoumalone

Overview

Nicoumalone is an anticoagulant, with actions, interactions and adverse effects similar to warfarin.

Category:

Primary Characterstics

Molecular Structure of Nicoumalone
. It is of Semi Synthetic origin and belongs to Coumarin. It belongs to Epoxide Reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Anticoagulants pharmacological group.The Molecular Weight of Nicoumalone is 353.30.

Pharmacokinetics

Oral absorption of Nicoumalone is found to be 83% ±7. Volume of distribution is found to be 0.3 l/kg and plasma protien binding is 98 %. and metabolism is reported extensive. Renal Excretion accounts for 60 % and plasma half life is 8 hr.

Indications

Contraindications

Nicoumalone is contraindicated in conditions like Haemorrhage,Cerebrovascular disease.

Drug Interactions

Nicoumalone is known to interact with other drugs, the details of drug interactions is as follows:

DrugDetailsSeverityOnsetManagement
Aspirin
Carbamazepine
Cimetidine (HCl)
Clopidogrel
Co-Trimoxazole
Metronidazole
Phenobarbitone
Sulphinpyrazone
Sulphinpyrazone
Vitamin K

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

  • Urinanalysis
  • Increased values of hepatic enzymes

Side Effects

The severe or irreversible adverse effects of Nicoumalone, which give rise to further complications include Skin necrosis.

Nicoumalone produces potentially life-threatening effects which include Hemorrhage, GI bleeding, Hematuria, Bruising. which are responsible for the discontinuation of Nicoumalone therapy.

The signs and symptoms that are produced after the acute overdosage of Nicoumalone include Bleeding.

Available Brands

No Brands Available.

Dosage

Nicoumalone's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

0.014 to 0.114 mg/kg0.064 (0.064)As recommended.POMaintenance, As required
0.114 to 0.171 mg/kg0.14 (0.1425)24 hourlyPOInitial, Reduce dose on second day

Paedriatic Dosage ( 20 Kg. )

Not recommended for this age group

Neonatal Dosage ( 3 Kg. )

Not recommended in this age group

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Nicournalone should be used with caution in patients with ulcers, unusual menstrual periods, diabetes, liver or kidney disease, high blood pressure, arthritis, thyroid problems, all recent infections, if have had recent surgery or of drug and food allergies. If patient have an illness that causes vomiting, diarrhea or fever for more than a few days, contact the doctor as these problems can change the effect of drug. Limit consumption of alcoholic beverages. Avoid sudden changes in dietary habits, Avoid ingesting unusual increases or decreases of foods high in Vitamin K (e.g.liver, cauliflower, cabbage, spinach and other green leafy vegetables, green tea, certain vegetables, cheeses and certain vitamin supplements). It is best to avoid strictly vegetarian diets that consist of foods high in vitamin K. Be extra careful to avoid injuries, because this medication can cause heavy bleeding. Be careful while brushing teethes or use an electric razor. It should not be used during pregnancy. It should be used with caution during lactation.

Storage Conditions

Tab

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