Ascorbic Acid is also known as vitamin C. Ascorbic Acid is a water soluble vitamin. It is structurally related to monosaccharides and exists in nature in both a reduced and the oxidized form, dehydroit. It involves in different body functions. its supplements may be used in persons with chronic illness, burns, or certain blood disorders. Best sources of vitamin C is fresh fruits such as citrus fruits, strawberries, melons and leafy vegetables such as lettuce, cabbage and tomatoes, potatoes and green and red peppers.
Ascorbic Acid also known as Vitamin C, Vitamin C. . It is of Natural origin and belongs to Furanolactone. It belongs to Vitamin, Water Soluble pharmacological group.The Molecular Weight of Ascorbic Acid is 176.10. It is strongly acidic drug, 5.05% solution of the drug is isotonic and Its pKa is 4.2, 11.6.
Oral absorption of Ascorbic Acid is found to be 82.5% ±2.5. Plasma protien binding is Nill. Renal Excretion accounts for 85% and plasma half life is 16 days.
Ascorbic Acid is contraindicated in conditions like
Ascorbic Acid is known to interact with other drugs, the details of drug interactions is as follows:
Drug Details Severity Onset Management Aminophylline Bleomycin Chloramphenicol Chlorothiazide Desogestrel Erythromycin Ethinyloestradiol Hydrocortisone Iron Salts Ascorbic acid enhances iron absorption from the gut. Levonorgestrel Mestranol Methylamphetamine Gastrointestinal acidifying agents such as glutamic acid HCl and ascorbic acid may lower the blood levels and efficacy of amphetamines. Moderate Nafcillin Nitrofurantoin Paracetamol Ascorbic acid increases half life of acetaminophen. Rutin (Vitamin P) Rutin may increase absorption of Ascorbic Acid. Sodium Bicarbonate Sodium Succinate Sulphadiazine
These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interference in Pathology
False positive reactions in certain tests for glucose, uric acid, creatinine & occult blood Falsely elevated or false negative test results may be obtained from plasma, feces or urine samples
The severe or irreversible adverse effects of Ascorbic Acid, which give rise to further complications include Kidney oxalate stones.
Ascorbic Acid produces potentially life-threatening effects which include Failure of conception. which are responsible for the discontinuation of Ascorbic Acid therapy.
The signs and symptoms that are produced after the acute overdosage of Ascorbic Acid include Diarrhea, GI disturbances, Hemolysis in patients with G6PD deficiency.
The symptomatic adverse reactions produced by Ascorbic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Laxative effect.
Click on the appropriate strength of the dosage form to view its available brands.
Single Ingredient Inj: 100 mg/ml, Drops: 100 mg/ml, Syrup: 200 mg/5ml, Sachet: 500 mg, Cream: 15 %w/w, Tabs: 1 g, 50 mg, 100 mg, 500 mg, Tabs efr: 1 g, Powder: 1 g/sachet, 0.5 g/sachet, Tabs Chewable: 500 mg, Multi ingredient
Inj: 30 mg/ml, 50 mg/ml, Inf: 500 mg, 400 mg/L, 500 mg/10ml, Drops: 50 mg/ml, 50 mg/0.6ml, Eye Drops: 0.25 %w/v, Syrup: 15 mg/5ml, 25 mg/5ml, 35 mg/5ml, 50 mg/5ml, 60 mg/5ml, 75 mg/5ml, 80 mg/5ml, 100 mg/5ml, 150 mg/5ml, 300 mg/5ml, 600 mg/5ml, 14.2 mg/5ml, 17.5 mg/5ml, 85.2 mg/5ml, 14.96 mg/5ml, 83.33 mg/5ml, Liquid: 125 mg/5ml, Sachet: 1 g, 20 mg, 100 mg, 150 mg, 250 mg, 500 mg, Tabs: 1 g, 15 mg, 20 mg, 30 mg, 45 mg, 50 mg, 60 mg, 75 mg, 90 mg, 100 mg, 120 mg, 150 mg, 200 mg, 220 mg, 250 mg, 300 mg, 500 mg, 600 mg, 750 mg, 1000 IU, 37.5 mg, Tabs efr: 75 mg, 500 mg, Caps: 15 mg, 30 mg, 40 mg, 50 mg, 60 mg, 75 mg, 100 mg, 120 mg, 150 mg, 250 mg, 300 mg, 500 mg, Soft Caps: 40 mg, Powder: 80 mg/L, 500 mg/sachet, Dragees: 150 mg, Tabs Chewable: 30 mg,
Ascorbic Acid's dosage details are as follows:
Eye drops 10%
100 to 1000 mg 550 (550) 24 hourly PO,IV,SC Frequency may be increased upto twice daily if needed. Dose vary according to requirement.
Paedriatic Dosage ( 20 Kg. )
25 to 50 mg 38 (37.5) 24 hourly Oral For Paeds of All Ages
Neonatal Dosage ( 3 Kg. )
6.25 to 3.125 mg/kg 4.7 (4.6875) 24 hourly oral
High Risk Groups
Drug should not be given to Pregnant Mothers.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Warning / Precautions
Ascorbic acid should be used with caution (if contains tartarazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma). Use with caution in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Avoid large dose of ascorbic acid, because it may cause renal calcium oxalate calculi.
Tab, Caps, Syrup
Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.
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