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Primary Characteristics PharmacoKinetics Indications Contra Indication
InteractionInterference in Pathology Side Effects Available Brands
Dosage High Risk Groups Warning / Precautions Storage Conditions
Trimethoprim
Introduction

Trimethoprim is a synthetic antibacterial agent, closely related to the antimalarial agent pyrimethamine. Chemically Trimethoprim is trimethoxybenzylpyrimidine. It has activity against both gram-positive and gram-negative bacteria. Trimethoprim is commonly used systemically for the treatment and prophylaxis of uncomplicated urinary tract infections, for traveler's diarrhea, and, when combined with either sulfamethoxazole or dapsone, for prophylaxis and treatment of Pneumocystis carinii infections. It was originally made available in combination with sulfamethoxazole in 1973, then was approved by the FDA for use as a single agent in 1980. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Trimethoprim is important to take the drug for the full time period as prescribed. Discontinuation of the drug, may result in ineffective treatment.

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