Glyceryl Trinitrate is a vasodialator (expands the blood vessels) Glyceryl Trinitrate is used for syptomatic treatment of angina to treat cardiac failure and during hypotensive or cardiac surgery to prevent myocardial infarction.
Glyceryl Trinitrate also known as Trinitrin, Trinitrin, Trinitrin, Trinitrin, Trinitrin. . It is of Synthetic origin and belongs to Nitropropane. It belongs to EDRF (NO) agonist pharmacological group on the basis of mechanism of action and also classified in Antianginal Agents and Vasodilators pharmacological group.The Molecular Weight of Glyceryl Trinitrate is 227.10.
Volume of distribution is found to be 3.3 l/kg and plasma protien binding is 60%. Presystemic metabolism is noted to be 75% ±5 and metabolism is reported primarily in Liver. Renal Excretion accounts for partial and plasma half life is 1-3 min.
Glyceryl Trinitrate is primarily indicated in conditions like
Anal fissure, Angina pectoris, Cardiac failure, Cardiopulmonary oedema, Long-term treatment of healed reflux oesophagitis, Moderate to severe reflux oesophagitis, Myocardial infarction, Oesophageal spasm, Oesophageal spasm, Postoperative hypertension, Prinzmetal's angina, Prophylaxis of angina, Unstable angina.
Glyceryl Trinitrate is known to interact with other drugs, the details of drug interactions is as follows:
Drug Details Severity Onset Management Alcohol Alprostadil Enhanced hypotensive effects when alprostadil given with Nitrates (e.g Glyceryl trinitrate). Apomorphine Sublingual apomorphine enhances hypotensive effecs of nitrates. Aspirin Atropine (Sulphate) Ergotamine (Tartrate) glyceryl trinitrate increase oral bioavailibilty and plasma concentration of dihydroergotamine in patients with orthostatic hypotension Heparin (Na) and Heparin (Cl) Imipramine (HCl) Quinagolide (HCl) Rauwolfia Reserpine Reserpine
These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interference in Pathology
False decrease in serum cholestrol by Zlotkis-Zak color reaction technique.
Increased urinary conc. of catecholamines and their metabolites.
The severe or irreversible adverse effects of Glyceryl Trinitrate, which give rise to further complications include Tachycardia, Bradycardia, Collapse.
The signs and symptoms that are produced after the acute overdosage of Glyceryl Trinitrate include Hypotension, Flushing, Tachycardia, Coma, Palpitations, Metabolic acidosis, Headache, Cardiovascular collapse, Syncope, Neurologic deficit, Methemoglobinemia, Increased intracranial pressure, Hypoxia, Cyanosis.
The symptomatic adverse reactions produced by Glyceryl Trinitrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Nausea, Vomiting, Restlessness, Palpitation, Abdominal pain, VertigoX, Urinary incontinence, Contact dermatitis, Syncope, Fecal incontinence, Orthostatic hypotension, dizziness.
Click on the appropriate strength of the dosage form to view its available brands.
Single Ingredient Inj: 1 mg/ml, Inf: 1 mg/ml, Aerosol: 0.4 mg, Patches: 5 mg, 10 mg, Spray: 400 mcg, Tabs: 2.6 mg, 6.4 mg, 6.5 mg, 500 mcg, Tabs SR: 2.6 mg, 6.4 mg, Tabs SL: 2 mg, 5 mg, 0.5 mg, Caps: 2.5 mg, 2.6 mg, 6.4 mg, Caps SR: 2.5 mg, 2.6 mg, 6.4 mg, 6.5 mg, Multi ingredient
Tabs: 0.5 mg,
Glyceryl Trinitrate's dosage details are as follows:
10 to 200 mcg 100 (105) As recommended. IV 300 to 600 ug 450 (450) As recommended. Sublingual placed under the tongue 3 doses of glyceryl trinitrate can be repeated every with in 15 minutes untill pain relieves.
400 ug 400 (400) As recommended. Topical (Aerosol spray)Each are directed on to or under the tongue.
Paedriatic Dosage ( 20 Kg. )
Not Recommended in this Age Group
Neonatal Dosage ( 3 Kg. )
Not recommended in this age group
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Warning / Precautions
Excessive use of glyceryl trinitrate may cause headache, so reduce the dose & use analgesics (painkiller). Patients with gastrointestinal (GI) hypermotality or malabsorption syndrome should take oral or sublingual sustained release capsules rather than tablets. In terminating treatment of angina, gradually reduced the dose in order to avoid withdrawal reactions. It should not be used in patients with severe hypotension, hypovolaemia marked anemia, heart failure due to obstruction, raised intracranial pressure or angle closure glaucoma. It should be used with caution in patients with impaired kidney or liver function or hypothyroidism.Hypothermia, cereberovascular disease disease lung disease, lung desease or cor pulmonole pregnancy,lactation mitral value prolopre syncope.
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