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Glyceryl Trinitrate

Overview

Glyceryl Trinitrate is a vasodialator (expands the blood vessels). Glyceryl Trinitrate is used for symptomatic or prophylactic treatment of angina, to treat cardiac failure and during hypotensive or cardiac surgery to prevent myocardial infarction.

Category:

Primary Characterstics

Molecular Structure of Glyceryl Trinitrate
Glyceryl Trinitrate also known as Trinitrin, Trinitrin, Trinitrin. . It is of Synthetic origin and belongs to Nitropropane. It belongs to EDRF (NO) agonist pharmacological group on the basis of mechanism of action and also classified in Antianginal Agents and Vasodilators pharmacological group.The Molecular Weight of Glyceryl Trinitrate is 227.10.

Pharmacokinetics

Volume of distribution is found to be 3.3 l/kg and plasma protien binding is 60%. Presystemic metabolism is noted to be 75% ±5 and metabolism is reported primarily in Liver. Renal Excretion accounts for partial and plasma half life is 1-3 min.

Indications

Contraindications

Drug Interactions

Glyceryl Trinitrate is known to interact with other drugs, the details of drug interactions is as follows:

DrugDetailsSeverityOnsetManagement
Alcohol
AlprostadilEnhanced hypotensive effects when alprostadil given with Nitrates (e.g Glyceryl trinitrate).
ApomorphineSublingual apomorphine enhances hypotensive effecs of nitrates.
Atropine (Sulphate)
Ergotamine (Tartrate)glyceryl trinitrate increase oral bioavailibilty and plasma concentration of dihydroergotamine in patients with orthostatic hypotension
Heparin (Na) and Heparin (Cl)
Imipramine (HCl)
Quinagolide (HCl)
Rauwolfia Reserpine
Reserpine

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

  • False decrease in serum cholestrol by Zlotkis-Zak color reaction technique.
  • Increased urinary conc. of catecholamines and their metabolites.

Side Effects

The severe or irreversible adverse effects of Glyceryl Trinitrate, which give rise to further complications include Tachycardia, Bradycardia, Collapse.

The signs and symptoms that are produced after the acute overdosage of Glyceryl Trinitrate include Hypotension, Flushing, Tachycardia, Coma, Palpitations, Metabolic acidosis, Headache, Cardiovascular collapse, Syncope, Neurologic deficit, Methemoglobinemia, Increased intracranial pressure, Hypoxia, Cyanosis.

The symptomatic adverse reactions produced by Glyceryl Trinitrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Nausea, Vomiting, Restlessness, Palpitation, Abdominal pain, VertigoX, Urinary incontinence, Syncope, Fecal incontinence, Orthostatic hypotension.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 1 mg/ml,
Inf: 1 mg/ml,
Aerosol: 0.4 mg,
Patches: 5 mg, 10 mg,
Spray: 400 mcg,
Tabs: 2.6 mg, 6.4 mg, 6.5 mg, 500 mcg,
Tabs SR: 2.6 mg, 6.4 mg,
Tabs SL: 2 mg, 5 mg, 0.5 mg,
Caps: 2.5 mg, 2.6 mg, 6.4 mg,
Caps SR: 2.5 mg, 2.6 mg, 6.4 mg, 6.5 mg,

Multi ingredient

Tabs: 0.5 mg,

Dosage

Glyceryl Trinitrate's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

0.5 to 1 mg0.75 (0.75)As recommended.SublingualAs required glyceryl trinitrate can be repeated every 3 minutes untill pain relieves.
5 to 10 mg7.5 (7.5)As recommended.Topicalglyceryl trinitrate 2% ointment can be used every 4-6 hours as required

Paedriatic Dosage ( 20 Kg. )

Not Recommended in this Age Group

Neonatal Dosage ( 3 Kg. )

Not recommended in this age group

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Excessive use of glyceryl trinitrate may cause headache, so reduce the dose & use analgesics (painkiller). Patients with gastrointestinal (GI) hypermotality or malabsorption syndrome should take oral or sublingual sustained release capsules rather than tablets. In terminating treatment of angina, gradually reduced the dose in order to avoid withdrawal reactions. It should not be used in patients with severe hypotension, hypovolaemia marked anemia, heart failure due to obstruction, raised intracranial pressure or angle closure glaucoma. It should be used with caution in patients with impaired kidney or liver function or hypothyroidism.

Storage Conditions

inj, Tab, spra y

Store Between 20°C-25°C.

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