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Oxytetracycline (Dihydrate)

Overview

Oxytetracycline (Dihydrate) is a naturally occuring tetracycline, produced by Streptomyces rimosis. Like other tetracycline it has a broad spectrum of activity.it was introduced in 1950. Effective against a wide range of both gram positive and gram negative organisms.The main mechanism of action is on protien synthesis. In addtion to its antibiotic activity Oxytetracycline (Dihydrate) is also a chelating agent and will chelate Ca, Mg or Al ions in the gut. Oxytetracycline (Dihydrate) is administered orally and intramuculalrly. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Oxytetracycline (Dihydrate) is important to take the drug for the full time period as prescribed. Discontinuation of the drug may result in ineffective treatment.

Category:

Primary Characterstics

Molecular Structure of Oxytetracycline (Dihydrate)
Oxytetracycline (Dihydrate) also known as Glomycin, Glomycin, Glomycin, Glomycin, Glomycin. Oxytetracycline HCL is the derivative of Oxytetracycline (Dihydrate). It is of Semi Synthetic origin and belongs to Tetracycline. It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Tetracycline Derivative pharmacological group.The Molecular Weight of Oxytetracycline (Dihydrate) is 496.50.
Its pKa is 3.3, 3.7, 9.1.

Pharmacokinetics

Oral absorption of Oxytetracycline (Dihydrate) is found to be 60% . Volume of distribution is found to be 406.6 l/kg and plasma protien binding is 31%. Presystemic metabolism is noted to be 0.5% ±0.5 and metabolism is reported Hepatic. Renal Excretion accounts for 22.5% and plasma half life is 9.2 hr.

Indications

Contraindications

Oxytetracycline (Dihydrate) is contraindicated in conditions like Systemic lupus erythematosus.

Drug Interactions

Oxytetracycline (Dihydrate) is known to interact with other drugs, the details of drug interactions is as follows:

DrugDetailsSeverityOnsetManagement
Amphotericin B
Calcium Gluconate
Emetine (HCl)
Ichthammol
Neostigmine
Pyridostigmine (Br)
Riboflavin (Vitamin B2)Riboflavin interferes with the absorption and effectiveness of tetracyclines.
Sodium Bicarbonate
Vitamin K

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

  • Hingerty method for Urinary Catecholamine Measurements
  • Urinary Urobilinogen Excretion Test Levels

Side Effects

The severe or irreversible adverse effects of Oxytetracycline (Dihydrate), which give rise to further complications include Renal failure.

Oxytetracycline (Dihydrate) produces potentially life-threatening effects which include Staphylococcal enterocolitis, Fluminating diarrhea. which are responsible for the discontinuation of Oxytetracycline (Dihydrate) therapy.

The signs and symptoms that are produced after the acute overdosage of Oxytetracycline (Dihydrate) include Vomiting, Coma.

The symptomatic adverse reactions produced by Oxytetracycline (Dihydrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Anorexia, Diarrhea, Maculopapular rash, Dysphagia, Enterocolitis, Erythematous rash, Esophagitis, Leukopenia, Bulging of fontanelle, Esophageal ulceration.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 50 mg/ml,
Eye Oint: 1 %w/w, 0.5 %w/w,
Oint: 3 %w/w, 0.3 %w/w,
Tabs: 250 mg,
Caps: 250 mg, 500 mg,
Powder: 10 %w/w,

Multi ingredient

Eye Oint: 0.5 %w/w,

Dosage

Oxytetracycline (Dihydrate)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

250 to 500 mg380 (375)6 hourlyPO

Paedriatic Dosage ( 20 Kg. )

Not Recommended in Children under 12 Years

Neonatal Dosage ( 3 Kg. )

Not recommended in this age group

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Oxytetracycline should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma). Take appropriate measures if secondary infection occurs. Perform periodic lab evaluation of organ system (e.g. liver or kidney) in case of long term therapy.

Storage Conditions

Caps

Store Below 40°C. Protect from Sunlight and Moisture.

Eye Drops

Store in a well closed container, Below 40°C. Do not Freeze. Protect from Sunlight and Moisture.

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