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Levetiracetam

Overview

Levetiracetam is an anti-epileptic drug which is used for the adjunctive treatment of partial seizures, with or without secondary generalisation.

Category:

Primary Characterstics

. It is of Synthetic origin and belongs to Piracetan. . The Molecular Weight of Levetiracetam is 170.20.

Pharmacokinetics

Oral absorption of Levetiracetam is found to be 50% ±50. Volume of distribution is found to be 0.6l/kg and plasma protien binding is <10%. and metabolism is reported Enzymatic hydrol. Renal Excretion accounts for 66% and plasma half life is 7(6-8)hr.

Indications

Levetiracetam is primarily indicated in conditions like Anxiety, Epilepsy, Myoclonic seizures, and can also be given in adjunctive therapy as an alternative drug of choice in Alzheimer's disease, Autism, Iron deficiency anaemia, Neuropathic pain, Tourette's syndrome.

Contraindications

Levetiracetam is contraindicated in conditions like Breast feeding.

Drug Interactions

Levetiracetam is known to interact with other drugs, the details of drug interactions is as follows:

DrugDetailsSeverityOnsetManagement
Lacosamide

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interference in Pathology

No data regarding the pathological interferences produced by Levetiracetam is available.

Side Effects

The severe or irreversible adverse effects of Levetiracetam, which give rise to further complications include Thrombocytopenia, Neutropenia, Pancytopenia.

Levetiracetam produces potentially life-threatening effects which include Hepatic impairment. which are responsible for the discontinuation of Levetiracetam therapy.

The symptomatic adverse reactions produced by Levetiracetam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Vertigo, Headache, Drowsiness, Ataxia, Alopecia, Anorexia, Nervousness, Rashes, Depression, Somnolence, Tremor, Diplopia, Asthenia, Aggression, Alopecia, nervousness, Nervousness, dizziness, Ataxia, Weakness.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Inj: 500 mg/5ml,
Inj-IV: 500 mg/5ml,
Syrup: 100 mg/ml,
Soln: 100 mg/ml,
Oral Soln: 500 mg,
Tabs: 1 g, 250 mg, 500 mg, 750 mg, 500 mgg,

Dosage

Levetiracetam's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

1000 mg/day1000 (1000)As recommended.POAdditional dosing increments may be given (1000 mg/day additional every 2 weeks) to a maximum recommended daily dose of 3000 mg.

Paedriatic Dosage ( 20 Kg. )

20 mg20 (20)As recommended.POTo maximum of 60 mg/kg daily.

Neonatal Dosage ( 3 Kg. )

No data regarding the neonatal dosage details of Levetiracetam is available.

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Levetiracetam should be used with caution in patients with hepatic impairment (Halve dose in severe hepatic impairment due to cocomitant renal impairment); renal impairment (May need dose reduction a/c to creatinine clearance); pregnancy (use only if potential benefits outweighs risk); avoid sudden withdrawl.

Storage Conditions

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