Vemurafenib

Overview

Vemurafenib is a low molecular weight, orally available antineoplastic agent, inhibitor of BRAF serine-threonine kinase. Vemurafenib is indicated for BRAF V600 mutation-positive unrescectable or metastatic melanoma. Mutations in the BRAF gene which substitute the valine at amino acid position 600 results in constitutively activated BRAF proteins, which can cause cell proliferation in the absence of growth factors that would normally be required for proliferation.

Categories

No Categories Defined

Primary Characterstics

. It belongs to Antineoplastic pharmacological group.

Indications

Back to top

Pharmacokinetics

Back to top

Contraindications

Back to top

Drug Interactions

Back to top

Side Effects

The severe or irreversible adverse effects of Vemurafenib, which give rise to further complications include Epidermal necrolysis, Photosensitivity, Uveitis, Hypersensitivity reactions.

Vemurafenib produces potentially life-threatening effects which include Stevens Johnson syndrome, QT prolongation. which are responsible for the discontinuation of Vemurafenib therapy.

The symptomatic adverse reactions produced by Vemurafenib are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Nausea, Vomiting, Alopecia, Anorexia, Diarrhea, Myalgia, Constipation, Maculopapular rash, Pruritus, Erythema, Hypotension, Cough, Asthenia, Arthralgia, Dry skin, Peripheral neuropathy, Folliculitis, Pyrexia, Vasculitis, Musculoskeletal pain, Dysgeusia, Pain in upper & lower extremities, Back pain.

Back to top

Dosage

Vemurafenib's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

480 to 960 mg720 (720)2 hourlyPOIt can be taken with or without food. Missed doses can be taken 4 hours prior to the next dose. QTc prolongation may require dose reduction (i.e. 480mg)

Paedriatic Dosage (20kg)

No data regarding the Paedriatic dosage details of Vemurafenib is available.

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Vemurafenib is available.

High Risk Groups

Back to top

Warning / Precautions

Back to top

Storage Conditions

Store . Protect from Moisture.

Back to top

Interference in Pathology

Back to top

Brands / Trade Names of Vemurafenib

Back to top

Manufacturers of Vemurafenib in Pakistan

Back to top

Previous Drug Generic - Next Drug Generic


Suggested Pages