Cyanocobalamin

Overview

Cyanocobalamin is also called vitamin B12. It is the most recently discovered of the viatmin B series, was isolated from the liver fraction in 1948. Cyanocobalamin is a complex water soluble compound. It is made up of a porphyrin like ring with a central cobalt atom attached to a nucleotide. It is required in body for growth, cell production and for blood and nerve function. The source of vitamin B12 is microbial synthesis, it is not present in plants or cereal grains to a measurable extent. The chief dietary source is microbially derived vitamin B12 in meat, eggs and dairy products. Humans must obtain the vitamin from the dietary intake of animal products.

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

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Dosage

Cyanocobalamin's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

250 to 1000 mcg620 (625)As recommended.IMEvery alternate day for 1-2 weeks, Maintenance dose is given monthly.
100 mcg100 (100)24 hourlyIM, Deep SCFor 6-7 days. If response observed then same days on alternate days for 7 doses, then every 3-4 days for another 2-3 weeks, then monthly for life in Pernicious Anemia
1000 mcg1000 (1000)As recommended.Schilling test

Paedriatic Dosage (20kg)

3 to 5 ug /kg4 (4)24 hourlyIntra MuscularInitially for 2 or more weeks
3 to 5 ug/kg4 (4)24 hourlySubcutaneousInitially for 2 or more weeks
10 ug/kg10 (10)As recommended.SubcutaneousMaintenance, once in a month

Neonatal Dosage (3kg)

3 to 5 ug /kg4 (4)24 hourlyIntra MuscularInitially for 2 or more weeks
10 ug/kg10 (10)As recommended.Intra MuscularMaintenance, once in a month
3 to 5 ug/kg4 (4)24 hourlySubcutaneousInitially for 2 or more weeks
10 ug/kg10 (10)As recommended.SubcutaneousMaintenance, once in a month

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Cyanocobalamin

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