Domperidone
Overview
Domperidone is a dopamine blocking agent. Domperidone is antiemetic agent. Domperidone is also used to treat nausea and vomiting induced by cancer chemotherapy.
Categories
- 17 Gastrointestinal drugs
Primary Characterstics
Indications
Domperidone is primarily indicated in conditions like Acute nausea and vomiting, Delayed gastric emptying, Dyspepsia, Functional dyspepsia, Gastric distension pain due to pressure on the stomach, Gastro-oesophageal reflux disease, Nausea and vomiting, Nausea and vomiting (chemotherapy induced), Nausea and vomiting (L-dopa induced), Non-ulcer dyspepsia, Reflux oesophagitis, and can also be given in adjunctive therapy as an alternative drug of choice in Cytotoxic chemotherapy, Heart burn, Lactation.
Back to top
Pharmacokinetics
Back to top
Back to top
Back to top
Side Effects
Back to top
Dosage
Domperidone's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 10 to 20 mg | 15 (15) | 6 hourly | PO | 15-30 minutes before meal. It can be used for maximum 12 weeks. To a maximum dose of 80mg. |
| 30 to 60 mg | 45 (45) | 6 hourly | Suppository | |
Paedriatic Dosage (20kg)
|
| 250 to 0.4 ug/kg | 130 (125.2) | 8 hourly | Oral | 15-30 minutes before meal. It can be used for maximum 12 weeks. To a total daily dose of 80mg. |
| 30 to 120 mg | 75 (75) | 8 hourly | Suppository | |
Neonatal Dosage (3kg)
|
| 0.2 to 0.4 mg/kg | 0.3 (0.3) | 8 hourly | Oral | - |
High Risk Groups
Back to top
Warning / Precautions
Back to top
Storage Conditions
Back to top
Interference in Pathology
Back to top
Brands / Trade Names of
Domperidone
Back to top
Previous Drug Generic - Next Drug Generic