Pyrazinamide
Overview
Pyrazinamide is antituberculosis agent. Pyrazinamide is the pyrazine analogue of nicotinamide. Pyrazinamide is stable and quite inexpensive. It may be bacteriostatic or bacteriocidal against Mycobacterium tuberculosis depending on the concentration of drug attained at the site of infection. Resistance to drug emerges rapidly when the drug is used alone. Therefore Pyrazinamide is always given in combination with other antituberculosis drug.
Categories
- 6 Anti-infective drugs
- 6.2 Antibiotics, systemic
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Pyrazinamide's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 20 to 35 mg/ kg | 28 (27.5) | As recommended. | PO | Daily in 3-4 div.doses. Maximum dose: 3 g/24hr. Usually given during 1st 2 months of therapy. |
Paedriatic Dosage (20kg)
|
| 5 mg/kg | 5 (5) | 6 hourly | Oral | For Paeds of All Ages |
Neonatal Dosage (3kg)
|
| 5 mg/kg | 5 (5) | 6 hourly | Oral | |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Pyrazinamide
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