Pergolide
Overview
Pergolide is a synthetic ergot derivative and a dopaine agonist, directly stimulates both D1 and D2 receptors.Chemically Pergolide is 8-(methylthio)methyl]-6-propylergoline. Pergolide is used in Parkinson`s disease as an adjunct to levodopa/carbidopa, prolongs the response to Levodopa in patients with response fluctuation. The drug may also benefit patients not receiving Levodopa. It works by stimulating dopamine receptors in the brain.
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Pergolide's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 50 ug | 50 (50) | 12 hourly | PO | On days 2-4, then 100-200 ug daily every 3-4 days in 3 div.doses. |
| 150 ug | 150 (150) | As recommended. | PO | On day 1 at night. |
Paedriatic Dosage (20kg)
|
| | | | |
Neonatal Dosage (3kg)
|
| | | | Not recommended in this age group |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Pergolide
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