Amifostine

Overview

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

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Dosage

Amifostine's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

200 to 200 mg/m.sq200 (200)24 hourlyIVFor prevention of xerotamine infuse over 3 minutes started 15-30 minutes before Radiotherapy.
740 to 740 mg/m.sq740 (740)As recommended.IVTo reduce cisplatin induced renal toxicity if doses of cisplatin of less tgan 100 mg/m.sq are used. Give as IV infussion over 15 minutes starting no more than 30 minutes before the antineoplastic therapy.
910 to 910 mg/m.sq910 (910)24 hourlyIVSubsequent doses should be reduced to 740 mg/m.sq in patient unable tolerate the full dose.

Paedriatic Dosage (20kg)

740 to 740 mg/m2740 (740)As recommended.IVTo reduce cisplatin induced renal toxicity, if doses of cisplatin of less than 100mg/m2 are used. Gi
200 to 200 mg/m2/day200 (200)As recommended.IV-Inf

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Amifostine is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Amifostine

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Manufacturers of Amifostine in Pakistan

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