Cyanocobalamin

Overview

Cyanocobalamin is also called vitamin B12. It is the most recently discovered of the viatmin B series, was isolated from the liver fraction in 1948. Cyanocobalamin is a complex water soluble compound. It is made up of a porphyrin like ring with a central cobalt atom attached to a nucleotide. It is required in body for growth, cell production and for blood and nerve function. The source of vitamin B12 is microbial synthesis, it is not present in plants or cereal grains to a measurable extent. The chief dietary source is microbially derived vitamin B12 in meat, eggs and dairy products. Humans must obtain the vitamin from the dietary intake of animal products.

Categories

• 10 Drugs affecting the blood
  • 10.1 Antianemia drugs

• 27 Vitamins, minerals, tonics, and other susbstances

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Cyanocobalamin is contraindicated in conditions like Anaphylactic reactions, Tobacco amblyopia.

Drug Interactions

Side Effects

Dosage

Cyanocobalamin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
250 to 1000 mcg	620 (625)	As recommended.	IM	Every alternate day for 1-2 weeks, Maintenance dose is given monthly.
100 mcg	100 (100)	24 hourly	IM, Deep SC	For 6-7 days. If response observed then same days on alternate days for 7 doses, then every 3-4 days for another 2-3 weeks, then monthly for life in Pernicious Anemia
1000 mcg	1000 (1000)	As recommended.	Schilling test
Paedriatic Dosage (20kg)
3 to 5 ug /kg	4 (4)	24 hourly	Intra Muscular	Initially for 2 or more weeks
3 to 5 ug/kg	4 (4)	24 hourly	Subcutaneous	Initially for 2 or more weeks
10 ug/kg	10 (10)	As recommended.	Subcutaneous	Maintenance, once in a month
Neonatal Dosage (3kg)
3 to 5 ug /kg	4 (4)	24 hourly	Intra Muscular	Initially for 2 or more weeks
10 ug/kg	10 (10)	As recommended.	Intra Muscular	Maintenance, once in a month
3 to 5 ug/kg	4 (4)	24 hourly	Subcutaneous	Initially for 2 or more weeks
10 ug/kg	10 (10)	As recommended.	Subcutaneous	Maintenance, once in a month

High Risk Groups

No Information regarding High Risk Group is available.

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Cyanocobalamin

Manufacturers of Cyanocobalamin in Pakistan

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