Human Albumin

Overview

Human Albumin is a sterile, nonpyrogenic preparation of serum albumin obtained by fractionating blood, plasma, serum or placentas from healthy human donors. It maintains the blood volume. Human Albumin is used as plasma volume expander in the treatment of shock, burns and low level of blood protein to correct or prevent deficiency of blood volume. Human Albumin is aministered intravenously. It solutions were developed by the Cohn and his associates during the Second World War, specifically to provide an improved material for emergency transfusion to military casualties. A method was developed to produce relatively pure albumin solutions from large quantities of human plasma and this stil remains the basis of virtually all production of clinical albumin products.

Categories

• 11 Blood products and plasma substitutes
  • 11.1 Plasma substitutes

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Plasma half life is 3-24 hr.

Contraindications

Drug Interactions

Side Effects

The severe or irreversible adverse effects of Human Albumin, which give rise to further complications include Oedema.

Human Albumin produces potentially life-threatening effects which include Severe Hypotension, Severe hypotension, Transmission of infectious agent. which are responsible for the discontinuation of Human Albumin therapy.

The signs and symptoms that are produced after the acute overdosage of Human Albumin include Hypotension, Volume overload.

The symptomatic adverse reactions produced by Human Albumin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fever, Chills, Urticaria, Nausea and vomiting.

Dosage

Human Albumin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.5 to 1 g/ kg/dose	0.75 (0.75)	24 hourly	IV	Repeat every 1-2 days. Usual dose 25g. No more than 250g should be administered within 48 hours. Maximum dose 2g/kg/dose
100 to 200 ml	150 (150)	As recommended.	IV-inf	1-2 ml/min, of 25 % solution.
Paedriatic Dosage (20kg)
2.5 to 0 ml/kg	1.2 (1.25)	24 hourly	Intra Venous Infusion	Infuse over 30-60 Min
Neonatal Dosage (3kg)
250 to 500 mg/kg	380 (375)	24 hourly	Infusion	Over 30 to 60 minutes

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Human Albumin

Manufacturers of Human Albumin in Pakistan

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