Neostigmine

Overview

Neostigmine (Methylsulphate) is a potent reversible inhibitor of acetylcholinesterase and its use is inthe treatment of mysthania gravis. Neostigmine bromide and neostigmine methylsulphate are quaternary ammonium compound. The pharmacologic properties of neostigmine mimic those of acetylcholine. Neostigmine (Methylsulphate) is more polar and does not enter in the CNS. its effects on skeletal muscle is greater than that of physostigmine.Neostigmine bromide and neostigmine methylsulphate are available for oral, opthalmic and parentral administration.

Categories

• 1 Drugs used in anesthesia
  • 1.4 Muscle relaxants and cholinesterase inhibitors

• 20 Muscle relaxants and cholinesterase inhibitors

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Neostigmine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.02 mg/ kg	0.02 (0.02)	As recommended.	IM	For diagnosis of myasthenia gravis
0.5 to 2.5 mg	1.5 (1.5)	As recommended.	IV, IM, SC	Additional doses depend upon the patient response. Max. 10mg/day
75 to 300 mg	190 (187.5)	4 hourly	PO	Max. 180mg/day
500 ug	500 (500)	4 hourly	PO,S/C,IM	For paralytic ileus & postperative urinary retention.
Paedriatic Dosage (20kg)
50 to 0 ug/kg	25 (25)	As recommended.	Intra Venous	To severe neuromuscular blockade.
200 to 0 mg/kg	100 (100)	6 hourly	Oral	For Myasthenia grains.
Neonatal Dosage (3kg)
50 ug/kg	50 (50)	As recommended.	Intravenous	As required
0.5 to 1 mg/kg	0.75 (0.75)	6 hourly	Oral	For all ages

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Neostigmine

Manufacturers of Neostigmine in Pakistan

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