Solifenacin succinate
Overview
Solifenacin is a competitive muscarinic receptor antagonist. Muscarinic receptors play an important role in several major cholinergically mediated functions, including contractions of
urinary bladder smooth muscle and stimulation of salivary secretion.
Primary Characterstics
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Solifenacin succinate's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 5 to 10 mg | 7.5 (7.5) | 24 hourly | PO | It can be administered with or without food. In patients with sever renal impairment (CLcr < 30 ml/min) and moderate hepatic impairment; greater than 5 mg/day dose is not recommended. It should not be taken in case of sever hepatic impairment. |
Paedriatic Dosage (20kg)
|
| No data regarding the Paedriatic dosage details of Solifenacin succinate is available. |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Solifenacin succinate is available. |
High Risk Groups
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Warning / Precautions
Incase of angioedema, if involvement of the tongue, hypopharynx, or larynx occurs, solifenacin should be promptly discontinued and appropriate therapy and/or measures necessary to ensure a patent airway should be promptly provided.
Administered with caution to patients with clinically significant bladder outflow obstruction because of the risk of urinary retention.
Use with caution in patients with decreased gastrointestinal motility, narrow-angle glaucoma, reduced renal function, reduced hepatic function.
Its doses greater than 5 mg are not recommended in patients with severe renal impairment (CLcr <30
mL/min) and moderate hepatic impairment. while, it is not recommended for patients with severe hepatic impairment.
It should not be administered during nursing.
The safety and effectiveness in pediatric patients have not been established.
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Solifenacin succinate
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Manufacturers of
Solifenacin succinate
in Pakistan
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