Vinorelbine (Tartrate)
Overview
Vinorelbine (Tartrate) is a semi-synthetic, intravenous antineoplastic (anticancer) agent, belongs to the class of vinca alkaloids. Vinorelbine (Tartrate) is a derivative of vinblastine and has structural modifications distinctly different from other vinca alkaloids. The spectrum of activity of vinorelbine is similar to either vincristine or vinblastine, however, vinorelbine may have less neurotoxicity than vincristine. Vinorelbine was approved by the FDA for treatment of advanced non-small cell lung cancer (NSCLC) December 22, 1994. its activity in breast cancer is notable but still requires further investigation. Vinorelbine (Tartrate) is used alone or in combination with other anticancer drugs in the treatment of certain cancers such as lung cancer, breast cancer, ovarian cancer.
Categories
- 8 Antineoplastics, immunomodulators and drugs used in palliative care
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
The severe or irreversible adverse effects of Vinorelbine (Tartrate), which give rise to further complications include Bone marrow depression.
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Dosage
Vinorelbine (Tartrate)'s dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 25 to 30 mg/ sq.meter | 28 (27.5) | As recommended. | IV | Once in a Week |
Paedriatic Dosage (20kg)
|
| No data regarding the Paedriatic dosage details of Vinorelbine (Tartrate) is available. |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Vinorelbine (Tartrate) is available. |
High Risk Groups
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Warning / Precautions
Vinorelbine should be used with caution in patients with any pre-existing liver disease, kidney disease, lung disease, breathing trouble or any allergy. Because it may cause bleeding be careful when brushing or flossing teeth. Avoid contact with people that may have colds or flu or recently received the oral polio vaccine. Vinorelbine must be handled carefully because it can irritate the skin. Vinorlbine should be avoided if possible during pregnancy or lactation. A reliable form of contraception is recommended for use during therapy with this medication.
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Vinorelbine (Tartrate)
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Manufacturers of
Vinorelbine (Tartrate)
in Pakistan
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