Acetylcysteine

Overview

Acetylcysteine is the N-acetyl derivative of naturally occuring amino acid L-cysteine. It is a mucolytic agent and works on the lung to make the mucous thin, facilitate their removal and making breathing easier in bronchopulmonary disorders. Acetylcysteine is administered by instillation or nabulization. it is available in combination with hypermellose.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

No data regarding the interactions of Acetylcysteine was found.

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Side Effects

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Dosage

Imipramine (HCl)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

3 to 5 ml4 (4)4 hourlyInhalationAs 20% solution for mucolytic effect inhaled as nebulizer 3-4 times/day.
6 to 10 ml8 (8)6 hourlyNebulizer3-5ml of 20% solution as nebulizer for mucolytic effect. 2 Nebulizations in each nostril.
OpthalmicFor dry eye associated with abnormal mucus production, acetylcysteine, usually as a 5% solution with hypromellose, is given topically 3 or 4 times daily.
140 to 140 mg/Kg140 (140)As recommended.POThis is an initial dose for Paracetamol poisning. Give 140mg/Kg as 5% solution.
70 to 70 mg/Kg70 (70)4 hourlyPOFor Paracetamol poisning: Give 17 doses of 70mg/Kg after initial dose with an interval of 4 hours.
600 to 600 mg600 (600)As recommended.POAs mucolytic in usual dose of 600 mg daily as a single dose or in three divided doses.

Paedriatic Dosage (20kg)

0.125 mg/kg.min0.12 (0.125)As recommended.IV InfusionMaintenance for 20 Hours, As Required
10 mg/kg.min10 (10)As recommended.IV InfusionInitially for 15 Minutes
2 to 3 gm2.5 (2.5)12 hourlyPO

Neonatal Dosage (3kg)

0.125 mg/kg/min0.12 (0.125)As recommended.InfusionMaintenance, over 20 hrs., As required
10 mg/kg/min10 (10)As recommended.InfusionInitial , For 15 minutes

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Imipramine (HCl)

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Manufacturers of Acetylcysteine in Pakistan

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