Aminoglutethimide

Overview

Aminoglutethimide is antineoplastic agent, also called as anticancer drug. Aminoglutethimide is effective in the treatment of breast cancers to slow or stop the growth of abnormal cells. Aminoglutethimide is used in combination of different anticancer drugs to obtain most excellent therapeutic effects and minimize unwanted effects or toxicities.

Categories

Primary Characterstics

Indications

Back to top

Pharmacokinetics

Back to top

Contraindications

Back to top

Drug Interactions

Aminoglutethimide is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Digitoxin

Interaction of Digitoxin with Aminoglutethimide

Details: Metabolism of digitoxin accelerated (reduced effect).
Megestrol (Acetate)

Interaction of Megestrol (Acetate) with Aminoglutethimide

Alcohol

Interaction of Alcohol with Aminoglutethimide

Medroxyprogesterone (Acetate)

Interaction of Medroxyprogesterone (Acetate) with Aminoglutethimide

Details: Aminoglutethimide reduces the plasma concentration of Medroxyprogesterone (Acetate)
Hydrocortisone

Interaction of Hydrocortisone with Aminoglutethimide

Details: Aminoglutethimide accelerates the metabolism of hydrocortisone (reduced effects).
Progesterone

Interaction of Progesterone with Aminoglutethimide

Details: Aminoglutethimide reduces the plasma concentration of Progesterone.
Dexamethasone

Interaction of Dexamethasone with Aminoglutethimide

Details: Aminoglutethimide accelerates the metabolism of Dexamethasone (reduced effects).
Theophylline

Interaction of Theophylline with Aminoglutethimide

Details: Aminoglutethimide accelerates the metabolism of theophylline (reduced effects).
Tamoxifen (Citrate)

Interaction of Tamoxifen (Citrate) with Aminoglutethimide

Details: Aminoglutethimide reduces the plasma concentration of tamoxifen.
Nitrendipine

Interaction of Nitrendipine with Aminoglutethimide

Details: Aminoglutethimide may decrease the levels/effects of nitrendipine.

Moderate

Warfarin (Na)

Interaction of Warfarin (Na) with Aminoglutethimide

Details: Aminoglutethimide may increase the metabolism, via CYP isoenzymes, of Warfarin.
Management: Increase frequency of monitoring warfarin effects (eg, prothrombin time) with addition of aminoglutethimide. Monitor for decreased therapeutic effects of Warfarin if aminoglutethimide is initiated/dose increased, or increased effects if aminoglutethimide is discontinued/dose decreased.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Back to top

Side Effects

Back to top

Dosage

Aminoglutethimide's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
4.762 mg/kg4.8 (4.762)8 hourlyPO-

Paedriatic Dosage (20kg)
No data regarding the Paedriatic dosage details of Aminoglutethimide is available.

Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of Aminoglutethimide is available.

High Risk Groups

Back to top

Warning / Precautions

Back to top

Storage Conditions

Back to top

Interference in Pathology

Back to top

Brands / Trade Names of Aminoglutethimide

Back to top

Manufacturers of Aminoglutethimide in Pakistan

Back to top

Previous Drug Generic - Next Drug Generic


Suggested Pages