Chlorhexidine

Overview

Chlorhexidine is a cationic biguanide antiseptic. Chlorhexidine is antibacterial agent and topical disinfectant. Chlorhexidine is active against vegetative bacterias and mycobecterias and has moderate activity against fungi and viruses. Chlorhexidine is most effective agianst gram positive bacterias.
Chlorhexidine digluconate (CHG) are cationic disinfectants widely used in aqueous personal products such as eye drops, lotions and creams.
Chlorhexidine Acetate is a topical antiseptic, bactericide, strong function of broad-spectrum bacteriostasis, sterilization, used for disinfecting hands, skin, washing wounds.

Categories

Primary Characterstics

Indications

Chlorhexidine is primarily indicated in conditions like Abrasion, Bladder irrigation, Bleeding, Burns, Cuts, Gingivitis, Infected cracked skin, Minor burns, Minor scalds, Pleural and peritoneal irrigation, Skin infections, Skin lesions, Sunburn blisters, Ulcers, Urethral infection, Wounds irrigation in surgery, and can also be given in adjunctive therapy as an alternative drug of choice in Oral hygiene.

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Pharmacokinetics

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Contraindications

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Drug Interactions

Chlorhexidine is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Povidone-Iodine

Interaction of Povidone-Iodine with Chlorhexidine

Details: Concomitant administration of Chlorhexidine may possibly result in partial inactivation.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

The severe or irreversible adverse effects of Chlorhexidine, which give rise to further complications include Hemolysis.

The signs and symptoms that are produced after the acute overdosage of Chlorhexidine include Slurred speech, Photophobia, Photophobia, Hypersensitivity reactions, Shortness of breadth, Shortness of breadth, Hemolysis, Allergic skin reactions.

The symptomatic adverse reactions produced by Chlorhexidine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Allergic reactions, Photosensitivity, Skin irritation, Skin sensitization, Irritation of sensitive tissues, Dermatitis, Taste disturbances, Teeth discoloration, Staining of oral surfaces, Staining of tongue, Swelling of face.

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Dosage

Chlorhexidine's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

0.02 to 4 %2 (2.01)As recommended.TopicalAs Required

Paedriatic Dosage (20kg)

0.02 to 0.05 %0.035 (0.035)As recommended.TopicalAs Required

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Chlorhexidine is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Chlorhexidine

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