Diazoxide

Overview

Diazoxide is antihypertensive agent. Diazoxide is a relatively long acting parentrally administerd vasodilator. Diazoxide is useful in hypertensive emergencies to lower the blood pressure and to increase blood sugar level in hypoglycemia.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

Oral absorption of Diazoxide is found to be 90% ±5. Volume of distribution is found to be 0.2 l/kg and plasma protien binding is 90%. and metabolism is reported Hepatic. Renal Excretion accounts for major and plasma half life is 28 ± 8.3 hr.

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Contraindications

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Drug Interactions

Diazoxide is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Chlormethiazole (Edisylate)

Interaction of Chlormethiazole (Edisylate) with Diazoxide

Chlorothiazide

Interaction of Chlorothiazide with Diazoxide

Cisplatin

Interaction of Cisplatin with Diazoxide

Phenytoin (Na)

Interaction of Phenytoin (Na) with Diazoxide

Chlorthalidone

Interaction of Chlorthalidone with Diazoxide

Ethacrynic Acid

Interaction of Ethacrynic Acid with Diazoxide

Gliclazide

Interaction of Gliclazide with Diazoxide

Human Insulin

Interaction of Human Insulin with Diazoxide

Hydralazine (HCl)

Interaction of Hydralazine (HCl) with Diazoxide

Fosphenytoin

Interaction of Fosphenytoin with Diazoxide

Insulin Lispro

Interaction of Insulin Lispro with Diazoxide

Pioglitazone

Interaction of Pioglitazone with Diazoxide

Alprostadil

Interaction of Alprostadil with Diazoxide

Details: Enhanced hypotensive effects when alprostadil given with Diazoxide.
Propranolol (HCl)

Interaction of Propranolol (HCl) with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Propranolol.
Chlorpromazine (HCl)

Interaction of Chlorpromazine (HCl) with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide Chlorpromazine.
Frusemide or Furosemide

Interaction of Frusemide or Furosemide with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Frusemide.
Moxonidine

Interaction of Moxonidine with Diazoxide

Details: Enhanced hypootensive effect when Diazoxide given with Moxonidine.
Baclofen

Interaction of Baclofen with Diazoxide

Details: Enhanced hypootensive effect when Diazoxide given with Baclofen.
Tizanidine

Interaction of Tizanidine with Diazoxide

Details: Enhanced hypootensive effect when Diazoxide given with Tizanidine.
Estrogens Conjugated

Interaction of Estrogens Conjugated with Diazoxide

Details: Hypotensive effect of diazoxide antagonised by Estrogens.
Carbenoxolone (Na)

Interaction of Carbenoxolone (Na) with Diazoxide

Details: Hypotensive effect of diazoxide antagonised by Carbenoxolone.
Hydralazine (HCl)

Interaction of Hydralazine (HCl) with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Hydralazine.
Captopril

Interaction of Captopril with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Captopril.
Enalapril (Maleate)

Interaction of Enalapril (Maleate) with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Enalapril.
Prazosin

Interaction of Prazosin with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Prazosin.
Terazosin

Interaction of Terazosin with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Terazosin.
Alcohol

Interaction of Alcohol with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Alcohol.
Enflurane

Interaction of Enflurane with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Enflurane.
Halothane

Interaction of Halothane with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with general anesthetics (Halothane).
Ibuprofen

Interaction of Ibuprofen with Diazoxide

Details: Hypotensive effect of when diazoxide antagonised by Ibuprofen.
Indomethacin

Interaction of Indomethacin with Diazoxide

Details: Hypotensive effect of diazoxide antagonised by NSAIDs (Indomethacin).
Losartan (K)

Interaction of Losartan (K) with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Losartan.
Candesartan

Interaction of Candesartan with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Candesartan.
Tranylcypromine (Sulphate)

Interaction of Tranylcypromine (Sulphate) with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide gven with MAOIs (e.g. Tranylcypromine).
Phenelzine

Interaction of Phenelzine with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide gven with MAOIs (e.g.Phenelzine).
Glibenclamide

Interaction of Glibenclamide with Diazoxide

Details: Diazoxide antagonises hypoglycaemic effect of antidiabetics.
Insulin Aspart

Interaction of Insulin Aspart with Diazoxide

Details: Diazoxide antagonises hypoglycaemic effect of antidiabetics (insulin).
Fluphenazine

Interaction of Fluphenazine with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Fluphenazine.
Diazepam

Interaction of Diazepam with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given Diazepam.
Amlodipine (Besylate)

Interaction of Amlodipine (Besylate) with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Amlodipine.
Nifedipine

Interaction of Nifedipine with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Nifedipine.
Clonidine (HCl)

Interaction of Clonidine (HCl) with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Clonidine.
Dexamethasone

Interaction of Dexamethasone with Diazoxide

Details: Hypotensive effect of Diazoxide antagonised by Dexamethasone.
Beclomethasone (Dipropionate)

Interaction of Beclomethasone (Dipropionate) with Diazoxide

Details: Hypotensive effect of Diazoxide antagonised by Beclomethasone.
Hydrochlorothiazide

Interaction of Hydrochlorothiazide with Diazoxide

Details: Enhanced hypotensive effect when Diazoxide given with Hydrochlorothiaide.
Levodopa

Interaction of Levodopa with Diazoxide

Details: Enhanced hypootensive effect when Diazoxide given with Levodopa.
Methyldopa

Interaction of Methyldopa with Diazoxide

Details: Enhanced hypootensive effect when Diazoxide given with Methyldopa.
Ritodrine (HCl)

Interaction of Ritodrine (HCl) with Diazoxide

Details: Diazoxide may potentiate cardiovascular effects of intravenous ritodrine, especially cardiac arrhythmias or hypotension.
Aldesleukin

Interaction of Aldesleukin with Diazoxide

Details: Hypotensive effects may be enhanced by the concomitant administration of Diazoxide.
Moxisylyte

Interaction of Moxisylyte with Diazoxide

Details: Enhanced hypootensive effect when Diazoxide given with Moxisylyte.
Eplerenone

Interaction of Eplerenone with Diazoxide

Details: Concomitant use with diazoxide, MAOIs, pentoxifylline, prostacyclin analogues may enhance hypotensive effect of antihypertensives.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Diazoxide's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
1 to 3 mg/kg2 (2)24 hourlyFor hypersensitive crises:- Given with in seconds upto a maximum dose of 150mg & repeated after 5 to 15 minutes if required.
3 to 5 mg/kg4 (4)24 hourlyFor hypoglycemia:- Initial dose in 2 to 3 divided doses .
3 to 8 mg/kg5.5 (5.5)24 hourlyFor hypoglycemia:- Maintainance dose up to 7g.

Paedriatic Dosage (20kg)
No data regarding the Paedriatic dosage details of Diazoxide is available.

Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of Diazoxide is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Diazoxide

No Brands Available.

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Manufacturers of Diazoxide in Pakistan

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