Doxycycline

Overview

Doxycycline is a semi-synthetic, broad spectrum tetracycline antibiotic derived from methacycline. Tetracyclines are derivative of polycyclic naphthacenecarboxamide. They are bacteriostatic and effective against many gram positive and gram negative bacteria. Doxycycline is the first drug of choice for prophylaxis of "travelers diarrhoea".Doxycycline is administered orally. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular interval of time throughout the day and night as prescribed. Doxycycline (HCl) is important to take the drug for the full time period as prescribed. If you discontinue drug, it may result in ineffective treatment.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

Doxycycline is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Iron Salts

Interaction of Iron Salts with Doxycycline

Magnesium Oxides and Hydroxides

Interaction of Magnesium Oxides and Hydroxides with Doxycycline

Rifampicin

Interaction of Rifampicin with Doxycycline

Phenytoin (Na)

Interaction of Phenytoin (Na) with Doxycycline

Phenobarbitone

Interaction of Phenobarbitone with Doxycycline

Alcohol

Interaction of Alcohol with Doxycycline

Glymidine

Interaction of Glymidine with Doxycycline

Phenobarbitone

Interaction of Phenobarbitone with Doxycycline

Phenytoin (Na)

Interaction of Phenytoin (Na) with Doxycycline

Sodium Bicarbonate

Interaction of Sodium Bicarbonate with Doxycycline

Fosphenytoin

Interaction of Fosphenytoin with Doxycycline

Carbamazepine

Interaction of Carbamazepine with Doxycycline

Details: Carbamazepine accelerates metabolism of Doxycycline (reduced effect) and shortens the half life of doxycycline.
Chlorpheniramine (Maleate)

Interaction of Chlorpheniramine (Maleate) with Doxycycline

Details: It increases effects of chlotpheniramine. as it is is a CYP3A4 inhibitor
Clavulanic Acid

Interaction of Clavulanic Acid with Doxycycline

Riboflavin (Vitamin B2)

Interaction of Riboflavin (Vitamin B2) with Doxycycline

Details: Riboflavin interferes with the absorption and effectiveness of tetracyclines.
Sodium Picosulphate

Interaction of Sodium Picosulphate with Doxycycline

Details: Should not be use concurrently without doctors prescription.

Moderate

Sodium Acetate

Interaction of Sodium Acetate with Doxycycline

Details: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve increased renal elimination of tetracyclines when the urine becomes alkalinized.
Management: If these drugs must be used together, an alternating dosing schedule is recommended (three to four hours apart).

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Doxycycline's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
100 mg100 (100)24 hourlyPOMaintenance, As Required
200 mg200 (200)As recommended.POOn first day.

Paedriatic Dosage (20kg)
Not Recommended in this Age Group

Neonatal Dosage (3kg)
Not recommended under 12 yrs.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Doxycycline

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