Ephedrine

Overview

Ephedrine is a plant alkaloid. Ephedrine is now made synthetically. Ephedrine is a mixed action adrenergic agent. It occurs in various plants and has been used in china for over 2000 years. It was introduced in western medicine approximately 70 years ago as the first orally active sympathomimetics drug. Because Ephedrine is a noncatechol phenylisopropylamine. It has high bilavailibilty and long duration of action. Clinically Ephedrine is utilized when a prolonged duration of action is desired, particularly after oral administration. The main applications are as a nasal decongestant and as a pressor agent.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

Ephedrine is contraindicated in conditions like Hypertension, Thyrotoxicosis, Ischaemic heart disease, Prostatic hypertrophy.

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Drug Interactions

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Side Effects

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Dosage

Isopropyl Unoprostone's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
25 to 50 mg38 (37.5)As recommended.IM,SC
25 to 50 mg38 (37.5)As recommended.IM,SC,Slow IV
5 to 25 mg15 (15)As recommended.IVRepeated 5 to 10 minutes
0.5 to 1 %0.75 (0.75)As recommended.Nasal dropsfor the treatment of nasal congestion.
25 to 50 mg38 (37.5)4 hourlyPO

Paedriatic Dosage (20kg)
0.5 to 1 %0.75 (0.75)As recommended.NasalAs Required
1.5 mg/kg1.5 (1.5)8 hourlyOral-

Neonatal Dosage (3kg)
0.5 to 1 %0.75 (0.75)As recommended.NasalAs required
0.93 mg/kg0.93 (0.93)8 hourlyOral

High Risk Groups

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Warning / Precautions

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Storage Conditions

Elixir, Nasal Spray

Store in a well closed container, Below 40°C. Do not Freeze. Protect from Sunlight.

Tab, Inj, Caps

Store in a well closed container, Below 40°C. Protect from Sunlight.

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Interference in Pathology

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Brands / Trade Names of Isopropyl Unoprostone

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