Sirolimus
Overview
Sirolimus is a potent non-calcineurin inhibiting immunosuppressant. Sirolimus is given after kidney transplant to keep body from rejecting the new kidney. It can cause hyperlipidemias. It has been shown to possess antifungal and antineoplastic properties. Sirolimus is often given in conjunction with cyclosporin.
Everolimus
A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. Check for active clinical trials or closed clinical trials using this agent.
Categories
- 8 Antineoplastics, immunomodulators and drugs used in palliative care
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Drug Interactions
Sirolimus is known to interact with other drugs, the details of drug interactions is as follows:
Severity N/A
Cyclosporin A Interaction of Cyclosporin A with Sirolimus
VORICONAZOLE Interaction of VORICONAZOLE with Sirolimus
Details: Voriconazole may increase the serum concentration of sirolimus.
Management: Consider alternate therapy or reduce the dose
Interaction of Simeprevir with Sirolimus
Details: Concomitant use with sirolimus may result in mildly increased or decreased plasma concentrations of sirolimus
Management: monitor closely
These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
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Side Effects
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Dosage
Pseudoephedrine (HCl)'s dosage details are as follows:
| Dose
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Single Dose
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Frequency
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Route
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Instructions
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Adult Dosage
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| No data regarding the Adult dosage details of Pseudoephedrine (HCl) is available. |
Paedriatic Dosage (20kg)
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| No data regarding the Paedriatic dosage details of Pseudoephedrine (HCl) is available. |
Neonatal Dosage (3kg)
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| No data regarding the neonatal dosage details of Pseudoephedrine (HCl) is available. |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Pseudoephedrine (HCl)
Click on the desired strength of the dosage form to view its available brands.
Single Ingredient
Tabs: 5 mg, 10 mg, 0.25 mg, 0.75 mg,
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