Ganciclovir (Na)

Overview

Ganciclovir (Na) is antiviral agent. Ganciclovir (Na) is a guanosine analog. Ganciclovir (Na) is active against herpes simplex virus, varicella zoster and cytomegalovirus. its activity against cytomegalovirus is up to 100 times greater than that of acyclovir.

Categories

• 6 Anti-infective drugs
  • 6.5 Antivirals, systemic
  • 6.5.1 Herpes and cytomegalovirus infection

Page headings

Primary Characterstics

Indications

Ganciclovir (Na) is primarily indicated in conditions like Cytomegalovirus infection (risk of relapse or retinitis), Cytomegalovirus infections, Local infiltration, Prophylaxis in bone marrow transplant recipient.

Pharmacokinetics

Contraindications

Ganciclovir (Na) is contraindicated in conditions like Neutropenia, Thrombocytopenia, Pregnancy, Hypersensitivity to the drug, Breast feeding, Severe infections, see instruction.

Drug Interactions

Side Effects

Dosage

Ganciclovir (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
4.5 mg	4.5 (4.5)	8 hourly	Intraoccular implants	By Intraoccular implant release in to viterous cavity at a rate of 1.4 mcg per hour
5 to 5 mg/kg	5 (5)	12 hourly	IV	Treatment (For 14-21 days)
5 mg/kg	5 (5)	24 hourly	IV	Maintenance (Until adequate recovery of immunity)
1 g	1 (1)	8 hourly	Oral	For 5-8 months but its oral absorption is poor
Paedriatic Dosage (20kg)
				Safety not established
Neonatal Dosage (3kg)
				Safety not established

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Ganciclovir (Na)

Manufacturers of Ganciclovir (Na) in Pakistan

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