Spironolactone
Overview
Spironolactone is a potassium-sparing diuretic. Spironolactone is a synthetic 17-spirolactone steroid that is competititive antagonist of aldosterone. Spironolactone is used as an antihypertensive agent. It frequently is used to treat ascites associated with cirrhosis and also has been used as a diagnostic aid for primary hyperaldosteronism. Spironolactone is a poor agent for treating hypertension or generalized edema, although its effects can be additive with thiazide diuretics. It was approved by the FDA in 1960.
Primary Characterstics
Indications
Spironolactone is primarily indicated in conditions like All forms of epilepsy, Congestive heart failure, Electrolyte disorder, For prophylaxis in pregnancy, Hirsutism, Hyperaldoesteronism, Hypertension, Myoclonus, Nephrotic syndrome, Oedema, Oedema and ascites in cirrhosis of the liver, Parkinson's disease; drug-induced extrapyramidal symptoms, Primary hyperaldosteronism, Tobacco amblyopia and leber's optic atrophy.
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Spironolactone's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 50 to 100 mg | 75 (75) | 24 hourly | PO | |
Paedriatic Dosage (20kg)
|
| 1 to 1.5 mg/kg | 1.2 (1.25) | 12 hourly | Oral | - |
Neonatal Dosage (3kg)
|
| 1 to 1.5 mg/kg | 1.2 (1.25) | 12 hourly | Oral | - |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Spironolactone
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Manufacturers of
Spironolactone
in Pakistan
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