Ethacrynic Acid
Overview
Ethacrynic Acid is an antihypertensive agent. Ethacrynic Acid is a prototype drug of Loop Diuretics. Loop diuretics have a much greater diuretic effects than the thiazides. Ethacrynic Acid is a phenoxyacetic acid derivative containing an adjacent ketone and methylene group. The methylene group forms an adduct with the free sulfhydryl group of cysteine. The cysteine adduct appears to be the active form of the drug. It increases the urination and decreases the amount of water retained in the body. Ethacynic acid is especially useful in patients who require an agent with greater diuretic potential than those commonly employed.
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Ethacrynic Acid's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 25 to 50 mg | 38 (37.5) | 24 hourly | IV | If necessory, maintanance Acute pulmonary edema. |
| 50 to 1 mg | 26 (25.5) | As recommended. | PO | In edema Initially |
Paedriatic Dosage (20kg)
|
| 2.5 mg/kg | 2.5 (2.5) | 24 hourly | Oral | Can be Increased as per requirement ,avoid below 2 Yrs |
Neonatal Dosage (3kg)
|
| | | | Avid under 2 yrs. |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Ethacrynic Acid
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Manufacturers of
Ethacrynic Acid
in Pakistan
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