Aurothiomalate
Overview
Aurothiomalate is a parentrally administered preparation of Gold. Gold compounds were introduced for the treatment of rheumatoid arthritis in the 1920s. Aurothiomalate is administered intramuscularly as water soluble gold salt containing 50 % elemental gold. Gold therapy is indicated for active rheumatoid arthritis.
Categories
- 2 Analgesics, antipyretics, NSAIDs, antigout, and antirheumatics
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Aurothiomalate's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 0.714 mg/kg | 0.71 (0.714) | As recommended. | IM | Once in a Week, For 5 Months |
| 0.085 to 0.128 mg/kg | 0.11 (0.1065) | 24 hourly | PO | Gradually Increased over 3 Months |
Paedriatic Dosage (20kg)
|
| 0.25 to 0.5 mg/kg | 0.38 (0.375) | As recommended. | Intra Muscular | Initial, gradually increased |
| 1 mg/kg | 1 (1) | As recommended. | Intra Muscular | Maintenance per week for 6-8 Months |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Aurothiomalate is available. |
High Risk Groups
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Warning / Precautions
Do not use Penicillamine or antimalarial with gold salts such as aurothiomalate. Before initiating treatment rule out pregnancy, perform complete blood count, urine analysis, liver and renal function test. Use with caution in patients with compromised cardiovascular or cerebral circulation.
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Aurothiomalate
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Manufacturers of
Aurothiomalate
in Pakistan
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