Thioguanine
Overview
Thioguanine is antineoplastic\anticancer drugs. Thioguanine is structural analogue of naturally occuring purine, guanine, both used by cells for DNA synrhesis. It belongs to a class of antimetabolite, with actions and uses similar to that of mercaptopurine. Antimetabolite are the compound that bear a structural similarity to a natutally occuring substance, such as vitamin, nucleoside or amino acid. Thioguanine is used chiefly in the treatment of lymphoblastic leukemia. Thioguanine is usually given in combination with other anticancer drugs to obtain better results and minimize side effects or toxicity. Thioguanine is administered orally. It was approved by FDA in 1966.
Categories
- 8 Antineoplastics, immunomodulators and drugs used in palliative care
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
No data regarding the contra indications of Thioguanine is available.
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Side Effects
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Dosage
Thioguanine's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 100 mg/ sq.meter | 180 (183) | 12 hourly | PO | Over 3-5 days in conjunction with other cytotoxic drugs. |
Paedriatic Dosage (20kg)
|
| 1 to 2 mg/kg | 1.5 (1.5) | 12 hourly | Oral | For 5----7 days |
Neonatal Dosage (3kg)
|
| 1.65 mg/kg | 1.6 (1.65) | 12 hourly | Oral | For 4 days |
High Risk Groups
Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Thioguanine
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