Lignocaine

Overview

Lignocaine is a sodium channel blocking agent, used as a local anesthetic and antiarrhythmic agent. It stabilizes nerve cell membranes to prevent impulse conduction. Used topically or by injection for local anaesthesia in minor operations.Intravenous injection or infusion used to treat abnormal heart rhythms. Excessive doses also block motor impulses and normal cardiac conduction. It has a low incidence of toxicity and a high degree of effeciveness in arrhythmias. Lignocaine is one of the least cardiotoxic drug of the currently used sodium channel blocker.

Categories

• 1 Drugs used in anesthesia
  • 1.2 Local anesthetics

• 12 Cardiovascular drugs
  • 12.2 Antiarrhythmic drugs

• 28 Otic drugs

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Lignocaine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
50 to 300 mg	180 (175)	As recommended.	IV Inf	Max of 4mg/kg
50 to 100 mg	75 (75)	As recommended.	IV Inj	For ventricular arrythmias.
4.5 mg/ kg /dose	4.5 (4.5)	As recommended.	SC	Dose vary with procedure. do not repeat within two hours.
1 to 2 %	1.5 (1.5)	3 hourly	Topical	As Required
5 %	5 (5)	As recommended.	Topical	For spinal Anestheria as hyperbaric.
Paedriatic Dosage (20kg)
20 to 50 ug/kg.min	35 (35)	As recommended.	IV Infusion	Maintenance, As Required
0.5 to 1 mg/kg	0.75 (0.75)	As recommended.	Slow IV	Initially, As Required
2 %	2 (2)	3 hourly	Topical	As Required
Neonatal Dosage (3kg)
20 to 50 ug/kg.min	35 (35)	As recommended.	IV Infusion	Maintenance, As Required
0.5 to 1 mg/kg	0.75 (0.75)	As recommended.	Slow IV	Initially, As Required
2 %	2 (2)	3 hourly	Topical	As Required

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Lignocaine

Manufacturers of Lignocaine in Pakistan

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